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As healthcare practitioners, it is important to understand the significance of high sensitivity C-reactive protein (hs-CRP) in chronic diseases. C-reactive protein (CRP) is an acute-phase protein synthesized by the liver in response to injury or inflammation in the body.
What is hs-CRP?
hs-CRP is a variant of CRP that can detect lower levels of inflammation in the body. It is considered a biomarker for cardiovascular disease, as chronic inflammation is a key factor in the development of atherosclerosis or narrowing of blood vessels. High levels of hs-CRP have been associated with an increased risk of heart attack or stroke.
Interpreting hs-CRP levels
hs-CRP levels are measured in milligrams per liter (mg/L). A level of less than 1mg/L is considered low risk, 1-3 mg/L is considered intermediate risk, and greater than 3 mg/L is considered high risk for cardiovascular disease.
It is important to note that hs-CRP is not specific to cardiovascular disease and may be elevated in other inflammatory conditions such as rheumatoid arthritis or infection. Therefore, interpretation of hs-CRP levels should be accompanied by a thorough medical history and physical examination.
Testing for hs-CRP
hs-CRP can be measured through a blood test. Testing is typically recommended for individuals who have intermediate risk for cardiovascular disease or for those with a family history of heart disease. It may also be used to monitor the response to treatment for cardiovascular disease.
Conclusion
As healthcare professionals, understanding the significance of hs-CRP in chronic diseases such as cardiovascular disease can aid in early detection and prevention. Interpretation of hs-CRP levels should be accompanied by a thorough medical history and physical examination. Testing for hs-CRP is recommended for individuals with intermediate risk for cardiovascular disease or those with a family history of heart disease.
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